GHS Hazard Statements | H315 (99.9%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (88.24%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
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Hazardous Substances Data Bank (HSDB)
Tris is a primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 7--9; pKa = 8.3 at 20 ℃; pKa = 7.82 at 37 ℃. It has a role as a buffer. It is a triol and a primary amino compound. It is a conjugate base of a member of Htris.
An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)
SLIGHT, CHARACTERISTIC ODOR
When heated to decomposition it emits toxic fumes of /nitrogen oxide/.
- Nasal bacterial colonization [ Time Frame: Day 5 of placebo or Tham intervention ]Culture
- Safety assessment questionnaire [ Time Frame: Day 5 of placebo or Tham intervention ]Questionnaire for local side effects
Full Title: Effects of Tromethamine on Cerebral Oxygenation and Metabolism in Patients Suffering Intractable Intracranial Hypertension – an exploratory study. | ||
Medical condition: Critically ill patients (SAH, ICB, AVM bleedings, malignant MCA infarcts) under sedation and mechanical ventilation in need of multimodality monitoring, including brain tissue oxygen monitoring and... |
Full Title: Influence of brain tissue pH regulation on cerebral oxygenation and metabolism in patients with severe traumatic brain injury. | ||
Medical condition: Severe traumatic brain injury |
... Prepared by reduction of tris(hydroxymethyl)nitromethane.
May be prepared by reducation or catalytic hydrogenation of the corresponding nitro compd. ... Preparation by by electrolytic reduction: McMillan, US patent 2485982 (1949 to Comm Solvents Corp)
Microbiocide
Pictogram(s) | |
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Signal | Warning |
GHS Hazard Statements | H302+H332 (12.41%): Harmful if swallowed or if inhaled [Warning Acute toxicity, oral; acute toxicity, inhalation] H302 (85.4%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (42.34%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (42.34%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332 (13.14%): Harmful if inhaled [Warning Acute toxicity, inhalation] H335 (27.74%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] H400 (52.55%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard] H410 (52.55%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] |
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